MS4078 chemical structure

MS4078

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S0072-5mg

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$118.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
MS4078 chemical structure

MS4078

$118.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
2229036-62-6
Formula
C45H52ClN9O8S
Small target
ALK
Smiles
CC1=CC(=C(C=C1C2CCN(CC2)CC(=O)NCCNC3=CC=CC4=C3C(=O)N(C4=O)C5CCC(=O)NC5=O)OC(C)C)NC6=NC=C(C(=N6)NC7=CC=CC=C7S(=O)(=O)C(C)C)Cl
Storage conditions
3 years -20°C powder
Scientific background
MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.
Technical documents

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MSDS

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