Isuzinaxib (APX-115 free base)

Name: Isuzinaxib (APX-115 free base)
Brand: Selleckchem
Price: 118.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Immunology & Inflammation

SKU: S0777-5mg

$118.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Immunology & Inflammation

Cas number

1270084-92-8

Formula

C17H17N3O

Small target

NADPH-oxidase

Smiles

CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3

Storage conditions

3 years -20°C powder

Synonyms

Ewha-18278 free base

Background

Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.

Isuzinaxib (APX-115 free base)

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Product Overview

Background

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