ABT-737 chemical structure

ABT-737

Vendor: Selleckchem

Type: Apoptosis

SKU: S1002-5mg

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ABT-737 chemical structure

ABT-737

$125.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Big target
Apoptosis
Cas number
852808-04-9
Formula
C42H45ClN6O5S2
Small target
Bcl-2
Smiles
CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
Storage conditions
2 years -80 in solvent
Scientific background
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
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