Linifanib (ABT-869) chemical structure

Linifanib (ABT-869)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1003-5mg

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Linifanib (ABT-869) chemical structure

Linifanib (ABT-869)

$90.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
796967-16-3
Formula
C21H18FN5O
Small target
CSF-1R
Smiles
CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
Storage conditions
2 years -80 in solvent
Synonyms
AL39324,RG3635
Scientific background
Linifanib (ABT-869, AL39324, RG3635) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3). Linifanib (ABT-869) induces autophagy and apoptosis. Phase 3.
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