Selumetinib (AZD6244) chemical structure

Selumetinib (AZD6244)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1008-200mg

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Selumetinib (AZD6244) chemical structure

Selumetinib (AZD6244)

$208.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
606143-52-6
Formula
C17H15BrClFN4O3
Small target
MEK
Smiles
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
Storage conditions
2 years -80 in solvent
Synonyms
ARRY-142886
Scientific background
Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.
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