Cediranib (AZD2171) chemical structure

Cediranib (AZD2171)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1017-5mg

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Cediranib (AZD2171) chemical structure

Cediranib (AZD2171)

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
288383-20-0
Formula
C25H27FN4O3
Small target
VEGFR
Smiles
CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5
Storage conditions
2 years -80 in solvent
Synonyms
NSC-732208
Scientific background
Cediranib (AZD2171, NSC-732208) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3 in HUVEC cells. Cediranib (AZD2171) induces autophagic vacuole accumulation. Phase 3.
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