Lenalidomide chemical structure

Lenalidomide

Vendor: Selleckchem

Type: Apoptosis

SKU: S1029-1g

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Lenalidomide chemical structure

Lenalidomide

$728.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Big target
Apoptosis
Cas number
191732-72-6
Formula
C13H13N3O3
Small target
TNF-alpha
Smiles
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
Storage conditions
2 years -80 in solvent
Synonyms
CC-5013
Scientific background
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
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