Sorafenib tosylate

Name: Sorafenib tosylate
Brand: Selleckchem
Price: 503.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1040-50mg

$503.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Protein Tyrosine Kinase

Cas number

475207-59-1

Formula

C21H16ClF3N4O3.C7H8O3S

Small target

PDGFR

Smiles

CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Storage conditions

2 years -80 in solvent

Synonyms

BAY 43-9006 tosylate,NSC-724772 tosylate

Background

Sorafenib tosylate is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

Sorafenib tosylate

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Product Overview

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