Sorafenib tosylate chemical structure

Sorafenib tosylate

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1040-50mg

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Sorafenib tosylate chemical structure

Sorafenib tosylate

$503.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
475207-59-1
Formula
C21H16ClF3N4O3.C7H8O3S
Small target
PDGFR
Smiles
CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Storage conditions
2 years -80 in solvent
Synonyms
BAY 43-9006 tosylate,NSC-724772 tosylate
Scientific background
Sorafenib tosylate is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Technical documents

Documents

MSDS

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