Tozasertib (VX-680)

Name: Tozasertib (VX-680)
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Cell Cycle

SKU: S1048-25mg

$110.00 USD

Shipping calculated at checkout.

Documents

MSDS

Available in stock (500)

Customs clearance fees may apply
Worldwide shipping available.

For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Cell Cycle

Cas number

639089-54-6

Formula

C23H28N8OS

Small target

Aurora Kinase

Smiles

CC1=CC(=NN1)NC2=CC(=NC(=N2)SC3=CC=C(C=C3)NC(=O)C4CC4)N5CCN(CC5)C

Storage conditions

2 years -80 in solvent

Synonyms

MK-0457

Background

Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.

Tozasertib (VX-680)

Documents

Product Overview

Background

Documents

Documents

Product Citations

More Info