Olaparib (AZD2281) chemical structure

Olaparib (AZD2281)

Vendor: Selleckchem

Type: DNA Damage/DNA Repair

SKU: S1060-10mg

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$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Olaparib (AZD2281) chemical structure

Olaparib (AZD2281)

$148.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
DNA Damage/DNA Repair
Cas number
763113-22-0
Formula
C24H23FN4O3
Small target
PARP
Smiles
C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Storage conditions
2 years -80 in solvent
Synonyms
Ku-0059436
Scientific background
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.
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