Crizotinib chemical structure

Crizotinib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1068-5mg

Explore specifications & documents
$110.00 USD
Shipping calculated at checkout.

Documents

MSDS

Available in stock (500)

Request a quotation
  • Customs clearance fees may apply
  • Worldwide shipping available.
For research use only — not intended for clinical or diagnostic purposes.
Crizotinib chemical structure

Crizotinib

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
877399-52-5
Formula
C21H22Cl2FN5O
Small target
ALK
Smiles
CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Storage conditions
2 years -80 in solvent
Synonyms
PF-02341066
Scientific background
Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
Technical documents

Documents

MSDS

A PARTNER IN YOUR RESEARCH

More time for discovery. Less time sourcing.

Bring your laboratory requirements together with scientific advice, global sourcing and dedicated procurement support.

Explore our services

Starting a new laboratory?

Plan your laboratory with our New-Lab programme.

Discover New-Lab