Foretinib chemical structure

Foretinib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1111-5mg

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For research use only — not intended for clinical or diagnostic purposes.
Foretinib chemical structure

Foretinib

$128.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
849217-64-7
Formula
C34H34F2N4O6
Small target
c-Met
Smiles
COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
Storage conditions
2 years -80 in solvent
Synonyms
GSK1363089, EXEL-2880, XL-880, GSK089
Scientific background
Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
Technical documents

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