Cabozantinib (XL184)

Name: Cabozantinib (XL184)
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1119-5mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Protein Tyrosine Kinase

Cas number

849217-68-1

Formula

C28H24FN3O5

Small target

c-Met

Smiles

COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F

Storage conditions

2 years -80 in solvent

Synonyms

BMS-907351

Background

Cabozantinib (XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.

Cabozantinib (XL184)

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Product Overview

Background

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