Cabozantinib (XL184) chemical structure

Cabozantinib (XL184)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1119-5mg

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Cabozantinib (XL184) chemical structure

Cabozantinib (XL184)

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
849217-68-1
Formula
C28H24FN3O5
Small target
c-Met
Smiles
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
Storage conditions
2 years -80 in solvent
Synonyms
BMS-907351
Scientific background
Cabozantinib (XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.
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