Sepantronium Bromide (YM155)

Name: Sepantronium Bromide (YM155)
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Apoptosis

SKU: S1130-5mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Apoptosis

Cas number

781661-94-7

Formula

C20H19BrN4O3

Small target

Survivin

Smiles

CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]

Storage conditions

2 years -80 in solvent

Background

Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.

Sepantronium Bromide (YM155)

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Product Overview

Background

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