Regorafenib chemical structure

Regorafenib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1178-5mg

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Regorafenib chemical structure

Regorafenib

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
755037-03-7
Formula
C21H15ClF4N4O3
Small target
c-RET
Smiles
CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
Storage conditions
2 years -80 in solvent
Synonyms
Fluoro-Sorafenib, BAY 73-4506
Scientific background
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.
Technical documents

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