Flavopiridol (Alvocidib)

Name: Flavopiridol (Alvocidib)
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Cell Cycle

SKU: S1230-5mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Cell Cycle

Cas number

146426-40-6

Formula

C21H20ClNO5

Small target

CDK

Smiles

CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

Storage conditions

2 years -80 in solvent

Synonyms

NSC 649890, HMR-1275, L86-8275

Background

Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.

Flavopiridol (Alvocidib)

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Product Overview

Background

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