Amuvatinib (MP-470) chemical structure

Amuvatinib (MP-470)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1244-50mg

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Amuvatinib (MP-470) chemical structure

Amuvatinib (MP-470)

$653.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
850879-09-3
Formula
C23H21N5O3S
Small target
c-Kit
Smiles
C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6
Storage conditions
2 years -80 in solvent
Synonyms
HPK 56
Scientific background
Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
Technical documents

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