Laduviglusib (CHIR-99021)

Name: Laduviglusib (CHIR-99021)
Brand: Selleckchem
Price: 148.0 USD
Availability: InStock

Vendor: Selleckchem

Type: PI3K/Akt/mTOR

SKU: S1263-2mg

$148.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

PI3K/Akt/mTOR

Cas number

252917-06-9

Formula

C22H18Cl2N8

Small target

GSK-3

Smiles

CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N

Storage conditions

2 years -80 in solvent

Synonyms

CT99021

Background

Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.

Laduviglusib (CHIR-99021)

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Product Overview

Background

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