BX-795 chemical structure

BX-795

Vendor: Selleckchem

Type: NF-κB

SKU: S1274-10mg

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BX-795 chemical structure

BX-795

$113.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
NF-κB
Cas number
702675-74-9
Formula
C23H26IN7O2S
Small target
IκB/IKK
Smiles
C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I
Storage conditions
2 years -80 in solvent
Scientific background
BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.
Technical documents

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