Rigosertib (ON-01910)

Name: Rigosertib (ON-01910)
Brand: Selleckchem
Price: 128.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Cell Cycle

SKU: S1362-5mg

$128.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Cell Cycle

Cas number

1225497-78-8

Formula

C21H24NNaO8S

Small target

PLK

Smiles

COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]

Storage conditions

2 years -80 in solvent

Background

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.

Rigosertib (ON-01910)

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Product Overview

Background

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