Ponatinib chemical structure

Ponatinib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S1490-10mg

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Ponatinib chemical structure

Ponatinib

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
943319-70-8
Formula
C29H27F3N6O
Small target
Bcr-Abl
Smiles
CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Storage conditions
2 years -80 in solvent
Synonyms
AP24534
Scientific background
Ponatinib is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.
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