Pioglitazone HCl chemical structure

Pioglitazone HCl

Vendor: Selleckchem

Type: Metabolism

SKU: S2046-10mg

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Pioglitazone HCl chemical structure

Pioglitazone HCl

$110.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Big target
Metabolism
Cas number
112529-15-4
Formula
C19H20N2O3S.HCl
Small target
P450 (e.g. CYP17)
Smiles
CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl
Storage conditions
2 years -80 in solvent
Synonyms
AD-4833, U-72107E
Scientific background
Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.
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