RAF265 (CHIR-265) chemical structure

RAF265 (CHIR-265)

Vendor: Selleckchem

Type: MAPK

SKU: S2161-5mg

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For research use only — not intended for clinical or diagnostic purposes.
RAF265 (CHIR-265) chemical structure

RAF265 (CHIR-265)

$128.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
MAPK
Cas number
927880-90-8
Formula
C24H16F6N6O
Small target
Raf
Smiles
CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
Storage conditions
2 years -80 in solvent
Scientific background
RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.
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