Buparlisib (BKM120) chemical structure

Buparlisib (BKM120)

Vendor: Selleckchem

Type: PI3K/Akt/mTOR

SKU: S2247-5mg

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Buparlisib (BKM120) chemical structure

Buparlisib (BKM120)

$128.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
PI3K/Akt/mTOR
Cas number
944396-07-0
Formula
C18H21F3N6O2
Small target
PI3K
Smiles
C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
Storage conditions
2 years -80 in solvent
Synonyms
NVP-BKM120
Scientific background
Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.
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