Rabusertib (LY2603618)

Name: Rabusertib (LY2603618)
Brand: Selleckchem
Price: 128.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Cell Cycle

SKU: S2626-5mg

$128.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Cell Cycle

Cas number

911222-45-2

Formula

C18H22BrN5O3

Small target

Chk

Smiles

CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OCC3CNCCO3

Storage conditions

2 years -80 in solvent

Synonyms

IC-83

Background

Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.

Rabusertib (LY2603618)

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Product Overview

Background

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