WYE-687 chemical structure

WYE-687

Vendor: Selleckchem

Type: PI3K/Akt/mTOR

SKU: S2668-5mg

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For research use only — not intended for clinical or diagnostic purposes.
WYE-687 chemical structure

WYE-687

$203.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
PI3K/Akt/mTOR
Cas number
1062161-90-3
Formula
C28H32N8O3
Small target
mTOR
Smiles
COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6
Storage conditions
2 years -80 in solvent
Scientific background
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
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