Trametinib (GSK1120212) chemical structure

Trametinib (GSK1120212)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S2673-5mg

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Trametinib (GSK1120212) chemical structure

Trametinib (GSK1120212)

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
871700-17-3
Formula
C26H23FIN5O4
Small target
MEK
Smiles
CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
Storage conditions
2 years -80 in solvent
Synonyms
JTP-74057
Scientific background
Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.
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