Flavopiridol (Alvocidib) HCl

Name: Flavopiridol (Alvocidib) HCl
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Cell Cycle

SKU: S2679-10mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Cell Cycle

Cas number

131740-09-5

Formula

C21H20ClNO5.HCl

Small target

CDK

Smiles

CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

Storage conditions

2 years -80 in solvent

Synonyms

NSC 649890, L86-8275, HMR-1275, DSP-2033

Background

Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.

Flavopiridol (Alvocidib) HCl

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Product Overview

Background

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