Dacomitinib chemical structure

Dacomitinib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S2727-5mg

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Dacomitinib chemical structure

Dacomitinib

$128.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1110813-31-4
Formula
C24H25ClFN5O2
Small target
EGFR
Smiles
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=CCN4CCCCC4
Storage conditions
2 years -80 in solvent
Synonyms
PF299804,PF299
Scientific background
Dacomitinib is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.
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