Crenolanib chemical structure

Crenolanib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S2730-5mg

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Crenolanib chemical structure

Crenolanib

$128.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
670220-88-9
Formula
C26H29N5O2
Small target
PDGFR
Smiles
CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4
Storage conditions
2 years -80 in solvent
Synonyms
CP-868596, ARO 002
Scientific background
Crenolanib is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
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