Niraparib (MK-4827) chemical structure

Niraparib (MK-4827)

Vendor: Selleckchem

Type: DNA Damage/DNA Repair

SKU: S2741-5mg

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$128.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Niraparib (MK-4827) chemical structure

Niraparib (MK-4827)

$128.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
DNA Damage/DNA Repair
Cas number
1038915-60-4
Formula
C19H20N4O
Small target
PARP
Smiles
C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
Storage conditions
2 years -80 in solvent
Scientific background
Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.
Technical documents

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