MK-2461 chemical structure

MK-2461

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S2774-5mg

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For research use only — not intended for clinical or diagnostic purposes.
MK-2461 chemical structure

MK-2461

$203.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
917879-39-1
Formula
C24H25N5O5S
Small target
c-Met
Smiles
CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)N=C2
Storage conditions
2 years -80 in solvent
Scientific background
MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.
Technical documents

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