Capmatinib chemical structure

Capmatinib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S2788-10mg

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Capmatinib chemical structure

Capmatinib

$128.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1029712-80-8
Formula
C23H17FN6O
Small target
c-Met
Smiles
CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F
Storage conditions
2 years -80 in solvent
Synonyms
INC280, NVP-INC280, INCB28060
Scientific background
Capmatinib is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.
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