(R)-(-)-Gossypol (AT-101) acetic acid

Name: (R)-(-)-Gossypol (AT-101) acetic acid
Brand: Selleckchem
Price: 353.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Apoptosis

SKU: S2812-50mg

$353.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Apoptosis

Cas number

866541-93-7

Formula

C30H30O8.C2H4O2

Small target

Bcl-2

Smiles

CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O.CC(=O)O

Storage conditions

2 years -80 in solvent

Background

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

(R)-(-)-Gossypol (AT-101) acetic acid

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Product Overview

Background

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