Linagliptin (GSK2118436)

Name: Linagliptin (GSK2118436)
Brand: Selleckchem
Price: 209.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Apoptosis

SKU: S3031-100mg

$209.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Apoptosis

Cas number

668270-12-0

Formula

C25H28N8O2

Small target

Ferroptosis

Smiles

CC#CCN1C2=C(N=C1N3CCCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

Storage conditions

2 years -80 in solvent

Synonyms

BI-1356

Background

Linagliptin (GSK2118436) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9. Linagliptin activates glomerular autophagy in a model of type 2 diabetes. DPP4 mediates ferroptosis in TP53-deficient CRC cells.

Linagliptin (GSK2118436)

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Product Overview

Background

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