Nuciferine

Name: Nuciferine
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Neuronal Signaling

SKU: S3821-5mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Neuronal Signaling

Cas number

475-83-2

Formula

C19H21NO2

Small target

5-HT Receptor

Smiles

CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)OC)OC

Storage conditions

2 years -80 in solvent

Synonyms

Sanjoinine E, (-)-Nuciferine, VLT 049

Background

Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.

Nuciferine

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Nuciferine

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