PCNA-I1 chemical structure

PCNA-I1

Vendor: Selleckchem

Type: Cell Cycle

SKU: S4476-5mg

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$365.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
PCNA-I1 chemical structure

PCNA-I1

$365.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Cell Cycle
Cas number
444930-42-1
Formula
C17H14N2O2S
Small target
DNA/RNA Synthesis
Smiles
CC1=C(SC=C1)C(=O)N\N=C\C2=C(O)C3=CC=CC=C3C=C2
Storage conditions
3 years -20°C powder
Scientific background
PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damage and apoptosis in both LNCaP and PC-3 cells. PCNA-I1 also induces autophagy in PC-3 cells.
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