Rolapitant chemical structure

Rolapitant

Vendor: Selleckchem

Type: Neuronal Signaling

SKU: S5476-5mg

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Rolapitant chemical structure

Rolapitant

$110.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Big target
Neuronal Signaling
Cas number
552292-08-7
Formula
C25H26F6N2O2
Small target
Neurokinin Receptor
Smiles
CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OCC2(CCC3(CCC(=O)N3)CN2)C4=CC=CC=C4
Storage conditions
3 years -20°C powder
Synonyms
SCH-619734
Scientific background
Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
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