BIO chemical structure

BIO

Vendor: Selleckchem

Type: PI3K/Akt/mTOR

SKU: S7198-10mg

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BIO chemical structure

BIO

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
PI3K/Akt/mTOR
Cas number
667463-62-9
Formula
C16H10BrN3O2
Small target
GSK-3
Smiles
C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O
Storage conditions
2 years -80 in solvent
Synonyms
GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052
Scientific background
BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.
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