Poziotinib chemical structure

Poziotinib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S7358-5mg

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Poziotinib chemical structure

Poziotinib

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1092364-38-9
Formula
C23H21Cl2FN4O3
Small target
HER2
Smiles
COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C
Storage conditions
2 years -80 in solvent
Synonyms
HM781-36B, NOV120101
Scientific background
Poziotinib is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib also induces apoptosis and G1 cell cycle arrest. Phase 2.
Technical documents

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