Lorlatinib (PF-6463922) chemical structure

Lorlatinib (PF-6463922)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S7536-5mg

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Lorlatinib (PF-6463922) chemical structure

Lorlatinib (PF-6463922)

$148.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1454846-35-5
Formula
C21H19FN6O2
Small target
ALK
Smiles
CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
Storage conditions
2 years -80 in solvent
Scientific background
Lorlatinib (PF-6463922) is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. PF-06463922 induces apoptosis. Phase 1.
Technical documents

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