WH-4-023 chemical structure

WH-4-023

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S7565-5mg

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WH-4-023 chemical structure

WH-4-023

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
837422-57-8
Formula
C32H36N6O4
Small target
Src
Smiles
CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C
Storage conditions
2 years -80 in solvent
Synonyms
KIN001-112, KIN112, Dual LCK/SRC inhibitor
Scientific background
WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Technical documents

Documents

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