Afatinib Dimaleate chemical structure

Afatinib Dimaleate

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S7810-10mg

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Afatinib Dimaleate chemical structure

Afatinib Dimaleate

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
850140-73-7
Formula
C24H25ClFN5O3.2C4H4O4
Small target
EGFR
Smiles
CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Storage conditions
2 years -80 in solvent
Synonyms
BIBW2992 Dimaleate
Scientific background
Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.
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