BIX-01294 trihydrochloride

Name: BIX-01294 trihydrochloride
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Epigenetics

SKU: S8006-10mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Epigenetics

Cas number

1392399-03-9

Formula

C28H38N6O2.3HCl

Small target

Histone Methyltransferase

Smiles

CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl

Storage conditions

2 years -80 in solvent

Background

BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.

BIX-01294 trihydrochloride

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Product Overview

Background

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