Agerafenib (CEP-32496) chemical structure

Agerafenib (CEP-32496)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S8015-5mg

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For research use only — not intended for clinical or diagnostic purposes.
Agerafenib (CEP-32496) chemical structure

Agerafenib (CEP-32496)

$203.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1188910-76-0
Formula
C24H22F3N5O5
Small target
CSF-1R
Smiles
CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F
Storage conditions
2 years -80 in solvent
Synonyms
RXDX-105
Scientific background
Agerafenib (CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.
Technical documents

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