Cobimetinib (GDC-0973) chemical structure

Cobimetinib (GDC-0973)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S8041-5mg

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Cobimetinib (GDC-0973) chemical structure

Cobimetinib (GDC-0973)

$148.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
934660-93-2
Formula
C21H21F3IN3O2
Small target
MEK
Smiles
C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Storage conditions
2 years -80 in solvent
Synonyms
RG7420,XL518
Scientific background
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, and showing no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.
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