Acalabrutinib (ACP-196)

Name: Acalabrutinib (ACP-196)
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S8116-5mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Protein Tyrosine Kinase

Cas number

1420477-60-6

Formula

C26H23N7O2

Small target

BTK

Smiles

CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5

Storage conditions

2 years -80 in solvent

Background

Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.

Acalabrutinib (ACP-196)

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Product Overview

Background

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