Acalabrutinib (ACP-196) chemical structure

Acalabrutinib (ACP-196)

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S8116-5mg

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Acalabrutinib (ACP-196) chemical structure

Acalabrutinib (ACP-196)

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1420477-60-6
Formula
C26H23N7O2
Small target
BTK
Smiles
CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5
Storage conditions
2 years -80 in solvent
Scientific background
Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.
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