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RSL3 chemical structure

RSL3

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THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Apoptosis
Cas number
1219810-16-8
Formula
C23H21ClN2O5
Small target
Ferroptosis
Smiles
COC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24
Storage conditions
2 years -80 in solvent
Synonyms
(1S,3R)-RSL3
Scientific background
RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.
Technical documents

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