Mivebresib (ABBV-075)

Name: Mivebresib (ABBV-075)
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Epigenetics

SKU: S8400-5mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Epigenetics

Cas number

1445993-26-9

Formula

C22H19F2N3O4S

Small target

Epigenetic Reader Domain

Smiles

CCS(=O)(=O)NC1=CC(=C(C=C1)OC2=C(C=C(C=C2)F)F)C3=CN(C(=O)C4=C3C=CN4)C

Storage conditions

2 years -80 in solvent

Background

Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell.

Mivebresib (ABBV-075)

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Product Overview

Background

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