Avapritinib chemical structure

Avapritinib

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: S8553-2mg

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Avapritinib chemical structure

Avapritinib

$110.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1703793-34-3
Formula
C26H27FN10
Small target
PDGFR
Smiles
CC(C1=CC=C(C=C1)F)(C2=CN=C(N=C2)N3CCN(CC3)C4=NC=NN5C4=CC(=C5)C6=CN(N=C6)C)N
Storage conditions
2 years -80 in solvent
Synonyms
BLU-285
Scientific background
Avapritinib is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM).
Technical documents

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